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Question of the Day


Could cannabinoid therapy modulate the spasticity and muscle cramps associated with ALS?

Clinical studies have suggested that cannabinoids may provide at least a subjective reduction of spasticity in patients with a motor neuron disease, although virtually all of the studies have been done in MS patients. A RCT using nabiximols in 189 MS patients reported a significant decrease of spasticity). A systematic review published for the American Academy of Neurology concluded that oral cannabis extracts are effective, and nabiximols and THC are probably effective in improving patient reported outcomes in those with MS, but not in changing short-term objective measures of spasticity.