Course created by Meredith Fisher-Corn, M.D. and Stephen B. Corn, M.D.
Copyright © 2024 The Answer Page. All rights reserved.
Table of Contents
Syllabus Topic I
The Endocannabinoid System and Phytocannabinoids
Part 1
- Endocannabinoid System (ECS)
- Definition of the Endocannabinoid System
- Components of the Endocannabinoid System
- Endocannabinoids
- N-arachidonoylethanolamine (also called anandamide)
- 2-arachidonoylglycerol (2-AG)
- Receptors
- Regulatory Enzymes
Part 2
- Pharmacology of Cannabis
- Components of cannabis
- Phytocannabinoids
- Delta-9-tetrahydrocannabinol (THC)
- Cannabidiol (CBD)
- Terpenes
- Interaction among phytocannabinoids
- Entourage Effect
Part 3
- Minor Phytocannabinoids
- Cannabinol (CBN)
- Cannabichromene (CBC)
- Cannabigerol (CBG)
- Tetrahydrocannabivarin (THCV)
Syllabus Topic II
The Administration and Dosing of Cannabis Products
(including contraindications, drug metabolism and drug interactions)
Part 1
- The Approved Cannabis Products and the Approved Modes of Administration in New York State
- Approved cannabis products and the approved modes of administration
- The dispensing of cannabis products
- The pharmacologic profile of vaporized cannabis
- The pharmacologic profile of orally administered cannabis
- The pharmacologic profile of oromucosally administered cannabis
Part 2
- Cannabis Dosing
- The reasons why there is no established set of guidelines for medical cannabis
- Avoiding unwanted side effects
- Lipophilicity of THC
- Preventing the misuse of cannabis
Part 3
- Contraindications to Medicinal Cannabis
- Absolute contraindications to medicinal cannabis
- Relative contraindications to medicinal cannabis
- Specific precautions for the use of cannabinoids in pediatric and elderly populations
- Absolute contraindications to cannabidiol (CBD) therapy
Part 4
- The Metabolism of Cannabis and Potential Drug Interactions
- The metabolism of cannabis
- Potential drug interactions between chemotherapy agents and cannabinoid medicines
- Potential drug interactions between antiretroviral medications and cannabinoid medicines
- Potential drug interactions between analgesic medications and cannabinoid medicines
- Potential drug interactions between anti-epileptic drugs and cannabidiol (CBD)
- Cytochrome P450 inhibitors
- Cytochrome P450 inducers
Syllabus Topic III
Physiological Effects and Adverse Effects of Cannabis
Part 1
- Clinical Physiology of Cannabis
- Effects on:
- Central nervous system
- Cardiovascular system
Part 2
- Side Effects and Adverse Reactions I
- Adverse Cannabis Reactions: cognition, pyschomotor performance, operating vehicles and machinery
Part 3
- Side Effects and Adverse Reactions II
- The relationship between exposure to cannabis and the development of psychosis and schizophrenia
- The relationship between exposure to cannabis and the development of depression
- The relationship between exposure to cannabis and the development of bipolar disorders
- The relationship between exposure to cannabis and suicide
Part 4
- Cannabis Use Disorder
- Recognition
- Diagnosis
- Treatment
- Strategies for risk evaluation
- Mitigation of the disorder
Part 5
- Cannabinoid Hyperemesis Syndrome
- Diagnostic criteria
- Laboratory markers of cannabinoid hyperemesis syndrome
- A comparison of cannabinoid hyperemesis syndrome to cyclical vomiting syndrome